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The primary endpoint was the proportion of patients who achieved LDA (based on DAS28-CRP 3.2) at Week 12

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The WHO suggested a range of regulatory options including banning vending machines from public places, stopping the sale of sweet, fruit and alcohol-flavoured products, and prohibiting manufacturers from touting the devices health benefits (such as their use in quitting smoking) until there is convincing supporting scientific evidence

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However, over time, it leads to decreased natural motivation, increased tolerance, and withdrawal symptoms that negatively impact performance and cognitive function