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Therapeutic doses have a minimal impact on the respiratory system, although high concentrations cause respiratory depression or oxygen displacement

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In tobacco, two compounds of concern are 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is derived from nitrosation of nicotine, and N-nitrosonornicotine (NNN), which is derived from nitrosation of nornicotine

Fourth edition.[xii] The forecast to 2025 is the author's linear extrapolation of data points from 2016 to 2023 for vapers and 2021 to 2023 for smokers

However, there were no significant dose-effect relationships between smoking amount and blood pressure when lifestyle and other confounding factors were considered