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performed a single-blind, randomized, crossover two-arm study to assess the effects of nicotine on the disposition kinetics of intravenously infused deuterium-labelled nicotine and cotinine and oral chlorzoxazone, verifying the hypotheses that nicotine reduces its own CYP2A6-mediated metabolism and induces CYP2E1 activity

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[8] For the US FDA's purposes, if a tobacco product meets the legal definition of a cigarette but the tobacco is not heated to a temperature high enough to cause combustion, the product would be currently categorized as a non-combusted cigarette and regulated as a cigarette

There is also some efficacy to leaving the tin to air out for a few days after opening, allowing some of the volatiles to dissipate

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July 22, 2011