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Nicotine stimulates the release of norepinephrine along with dopamine and serotonin, which is one reason why people feel more awake and focused after using nicotine

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"There is not sufficient evidence that (they) are safe products for human consumption," Timothy O'Leary, a communications officer at the WHO's Tobacco Free Initiative in Geneva, said this week

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Additionally, it has been found that chronic nicotine use leads to nAChR receptor desensitization and inactivation during stages of withdrawal, which are reactivated upon overnight abstinence (106, 107)

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