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The National Institutes of Health (awards R56HG011035, R01DA044283, R01DA042755, U01DA041120, R01GM126479, R03OD032630, R01HG011035, R56HG012358 and T32DA050560) and Penn State College of Medicines Biomedical Informatics and Artificial Intelligence Program supported this research

Trial Schedule: A trial centered on the issue of Zyn nicotine addiction is set to take place in December 2026

The best-fitting model for each partition was chosen by ModelFinder (Kalyaanamoorthy et al., 2017) using the -m MFP option with COI and CytB partitioned by codon position

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The compounds can resist traditional cleaning methods, calling for more specialized approaches