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Interestingly, combined administration of both alcohol and caffeine, pairwise PLS-DA model saline-water vs caffeine-alcohol (CER = 0.27), did not highlight differences in stearoyl-myristoyl-glycero-phosphocholine, PC-DAG, Lyso-PC (22:6), oleamide and in two of the predicted acyl-carnitines, suggesting that caffeine prevented alcohol-induced specific alterations of these molecules (Fig