In this study, we present the profiles of differentially expressed proteins in trachea tissue from smoke-exposed vs controls and relate the changed biological processes to mechanisms of disease development
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Abbreviations AD: Alzheimers disease ALS: amyotrophic lateral sclerosis AMPK: 5 AMP-activated protein kinase ARE: anti-oxidant response element ATBC: -tocopherol, -carotene cohort study BBB: bloodbrain barrier CARET: beta carotene and retinol efficacy trial CDC: Centers for Disease Control and Prevention (CDC) CDDO-Im: 1[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole COPD: chronic obstructive pulmonary disease CoQ10: coenzyme Q10 CS: cigarette smoke DM: diabetes mellitus GSH: glutathione GSTs: glutathione-S-transferases HF: heart failure HDLc: high-density lipoprotein cholesterol LDLc: LDL cholesterol MDA: malondialdehyde MF: metformin Nrf2: nuclear factor erythroid 2-related factor PD: Parkinsons disease PG: prostaglandin PAHs: polycyclic aromatic hydrocarbons PSH: Physicians Health Study RDA: recommended dietary allowance ROS: reactive oxygen species SHS: secondhand smoke SOD: superoxide dismutase Th2: T-helper 2 TS: tobacco smoke TSNAs: tobacco-specific nitrosamines TTC: triphenyl tetrazolium chloride XAR: xenobiotic-activated receptor UGTs: uridine-5-disphosphate-glucuronosyltransferases VLDL: very low density lipoprotein References Malerba M, Montuschi P
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