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Specifically, STUB1 (STIP1 homolog and U-box containing protein 1), an acknowledged E3 ubiquitin ligase for NOX4, promotes the degradation of Smad3 and NOX4, exerting a negative regulatory effect on the TGF- pathway (79)

Smoke from marijuana combustion has been shown to contain many of the same toxins, irritants and carcinogens as tobacco smoke

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