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Similar content being viewed by others Background It is well documented that there is a substantial social gradient in smoking behavior: among smokers, those who are more socially disadvantaged also smoke more heavily [1,2,3] and suffer worse health implications as a result [4, 5]

The use of nicotine-containing e-cigarettes has dramatically risen in pregnant and lactating women, with some people replacing traditional tobacco usage with e-cigarettes (Zeid et al., 2018)

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p = 0.008) per doubling of odds on PD, the MR-Egger estimate suggested the presence of unbalanced horizontal pleiotropy, suggesting multiple potential (independent) biological modes of action linking the smoking variants onto PD risk, although the point estimate remain widely consistent with the IVW findings

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