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According to the article, nicotine is mainly a potent activator of midbrain dopamine reward pathway, and its action on the locus ceruleus activates awareness, provocation, and attentiveness with anxiety activity, making nicotine users more attentive and creating dependency similar to other addictive drugs like cocaine and heroin

As one of the most widely consumed and controversial products on the planet, tobacco has a profound impact on our global society

[2] They can overlap with e-cigarettes such as a combination of an e-cigarette and a heated tobacco product, for the use of tobacco or e-liquid