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Psychiatry 22 , 13761384 (2017)

Ninety-nine percent used devices containing nicotine

These can include sugars, starch, other opiates, and quinine, which are added to increase bulk or alter the drugs effects

CONCLUSIONS This two-step Mendelian randomization study suggests a potential causal pathway from irritability to bipolar disorder, with smoking acting as a partial mediator

He may be kind of a rough and tumble guy, and probably a bit of an asshole IRL

Something similar happens with fruity scents like "Strawberry Shortcake" or "Mango Tango." They might conjure up images of juicy fruit on a summer day, but the artificial sweetness soon overwhelms, leaving you with an upset stomach instead of calm and bliss