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Observed effects in human trials Reported adverse events across the IV and oral trials included headache, fatigue, dizziness, nasopharyngitis, diarrhea, flatulence, increased appetite, nausea, and back pain

Instead, they exhibited higher angiotensin II type 1 receptor (AT1R) antibodies, lower 2B-adrenergic receptor antibodies, and significantly elevated IL-6 levels, changes that distinguished cases from controls

(2023) 11:e002919

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Flower-shaped lipid nanoparticles evade Apolipoprotein E-mediated liver tropism for safe and enhanced cytokine-based cancer immunotherapy

Derwa Y, Gracie DJ, Hamlin PJ, Ford AC