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Yet another embodiment of the invention, wherein the mainstream smoke solution is incapable of producing significant oxidative damage to guinea pig lung microsomal proteins in vitro One more embodiment of the invention related to use of nicotine fortified tobacco, which results in increase in delivery of nicotine without increasing the level of p-BSQ

But results vary because smoke changes with temperature, burn rate, and oxygen levels

PMC 5348619

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S2CID 8093704