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This scenario likely corresponds to individuals who start smoking late in life, smoke only infrequently, or quit before developing major illnesses

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Likewise, in murine macrophages, the activated 7nAChR can mediate Jak2-STAT3 activation and then can induce the phosphorylation of STAT3, which subsequently downregulates pro-inflammatory cytokines (e.g., IL6, IL12, and TNF-) [133]