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The term hardening is used in this context to refer to the residual smokers who either resist cessation efforts or who have more difficulty quitting than former smokers (Burns and Warner 2003)

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Research by Lucki and colleagues suggests that the ventral noradrenergic bundle may, however, play a more significant role in mediating the neurobehavioral effects of norepinephrine reuptake inhibitors than the dorsal noradrenergic bundle (Cryan et al., 2002b)

Now far ahead the Road has gone, And I must follow if I can, Pursuing it with eager feet, Until it joins some larger way Where many paths and errands meet

Yarnell, R

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