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Cigarettes provide a rapid nicotine spike to the bloodstream, while lozenges release nicotine gradually which can reduce intensity but help manage cravings more steadily

Only South Carolina still has the same rate today as it did in 1983

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The most severe form of cancer which is associated with smoking is oral cancer

The TTP favors the XL formulation because (a) it is taken once a day, which patients find facilitates easier adherence, and (b) it has been reported to cause fewer side effects (it has a slower uptake and decline in blood levels)