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Comparisons with other national surveys and sales data indicate the survey achieves nationally representative estimates of key variables including sociodemographic characteristics, smoking prevalence, and cigarette consumption [34, 36]

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TRPV1 + and TRPA1 + fibers detect thermal, mechanical, and chemical stimuli and are sensitized by inflammatory mediators such as IL-31 (91), resulting in heightened neuronal excitability and amplification of itch signaling (128)

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