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It releases a large amount of these endorphins

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These diseases cause oxidative stress in neurons that also produce peroxynitrite (ONOO ) from the reaction of superoxide anions and nitric oxide causing DNA damage with subsequent PARP-1 activation

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dated 1994, categorizes nicotine dependence as a disorder under substance-related and addictive disorders, while the ICD-10 (International Classification of Diseases, Tenth Revision) includes it in the section for mental and behavioral disorders due to psychoactive substance use