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Therefore, it would be recommended to use the combination with caution and to monitor the onset of early signs such as anxiety, confusion, disorientation and, if necessary, to discontinue drug treatment ( Finally, co-administration of bedaquiline with bupropion may cause an increased risk of hepatotoxicity, so it is better to avoid this association whenever possible, especially in patients who already have impaired liver function ( Possible interactions between antituberculous drugs and smoking cessation medications are summarised in Table 2

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