These covariates included HDL (high-density lipoprotein) cholesterol, LDL (low-density lipoprotein) cholesterol, HDL cholesterol ratio, triglycerides, sitting diastolic and systolic blood pressure (mean of three measures), history of high blood pressure, history of stroke or cardiovascular disease, Fazekas score, FEV1, alcohol units per week, hemoglobin A1c, diagnosis of diabetes, depression score from HADS, age-11 IQ and SES: Cortical thickness= b 0 Intercept+ b 1 Gender+ b 2 Exact_Age_At_Scanning+ b 3 PackYears + b 4 HDL_Cholesterol+ b 5 LDL_Cholesterol+ b 6 HDL_Cholesterol_Ratio+ b 7 Triglycerides+ b 8 Diastolic_Pressure+ b 9 Systolic_Pressure+ b 10 HighBloodPressureHistory + b 11 Stroke_History+ b 12 Fazekas_Score + b 13 Cardiovascular_Disease_History + b 14 FEV1+ b 15 Weekly_Alcohol_Units+ b 16 Hemoglobin_A1C+ b 17 Diabetes_Diagnosis + b 18 HADS+ b 19 Age-11_IQ+ b 20 SES+error To assess whether the association between smoking and cortical thickness varied as a function of the age of starting smoking, Models 2 and 3 were retested after including smoking starting age' and the smoking starting age' by pack-years' interaction term

The frequency of use and the amount of nicotine in tobacco products determines the severity of withdrawal symptoms, according to an article on nicotine withdrawal from Cleveland Clinic
"Harold Wilson obituary"
One says heated tobacco is closer to smoking
He described his experience removing sticks of dried tobacco from curing barns in central Kentucky in the winter of 2013: I had to climb up and down in the barn
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 19902019: a systematic analysis from the Global Burden of Disease Study 2019