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(b) methodological differences such as prospective or retrospective study design, definition and classification of smoking habits (active smoker, never smokers, ex-smokers), quantification of exposure (pack years, duration of cigarette smoking) classification of CKD (proteinuria, serum creatinine levels, eGFR), duration of follow-up after cessation of smoking, presence of comorbidities, life style, health care system, and medications