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In time, however, the body recalibrates and recovers, and the long-term sleep benefits will outweigh the brief sleep loss that follows smoking cessation

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As mtDNA copy number remained stable compared to CSE unexposed control cells, this increased gene expression level may be a compensatory cellular response in mtDNA transcription activity to the reduced mitochondrial respiration

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So in a way it takes the curse off the idea that, if we make a sequel then we have to use the same elements, and all that