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Specifically, different allelic variations in CYP2D6 influence enzyme activity leading to either ultra-metabolizers or poor-metabolizers of CYP2D6 substrates (175, 176)

While IQOS is an electronic device, the FDA has classified it as a cigarette, which means the product is subject to all the same existing restrictions for traditional cigarettes

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FIGURE 1 Below are selected examples of the pleiotropic effects of -blockers: - Metabolic effects: -blockers have been linked to metabolic effects, such as weight gain and potential implications in diabetes mellitus (Tomiyama and Yamashina, 2014), while several studies have suggested that vasodilatory -blockers may have beneficial effects on glucose and lipid metabolism (Peixoto et al., 2020

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Downregulation of glycolytic rate was HIF-dependent because HIF-1, the -subunit of HIF-1, was downregulated by CSE on the protein level, especially under normoxia