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12 2021 guidance by the National Institute for Health and Care Excellence (NICE) recommends that young people are discouraged from using e-cigarettes due to the potential higher chance of smoking in the future, and the recommended approach to treating tobacco dependence for those aged 12 to 17 is to consider nicotine replacement therapy (NRT) (together with behavioural support)

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It also considers the scenario of whether the region contains a variant that influences ND and a separate variant influences the other trait (model 4)