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During the trial, 1 subject who received Humira willingly discontinued and did not attend the follow-up visits (Fig

It has been established that these factors may have an aetiological role in the development of OL in more than 75% of the affected individuals

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This includes inhibitor therapies for NBL patients, which notably concentrate on ALK signaling, MDM2, PI3K/Akt/mTOR, Wnt, and RAS-MAPK pathways, along with regulators of epigenetic mechanisms