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Observed outcomes show that dogs and cats serve as effective sentinels for SHS exposure, and also reveal that they accumulate nicotine metabolites, particularly cotinine, in biological matrices such as urine, serum, fur, and even amniotic fluid, which may adversely affect their health 40-42

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Taken together, our in vitro model provides interesting insights into HIF-dependent regulation of glycolysis under normoxic conditions, which will enable us to investigate signaling pathways involved in RPE metabolism in health and disease