A previous study found that cholesterol crystals accumulated in the intima in the early stage of atherosclerosis can activate the inflammatory response of macrophages and smooth muscle cells through NLRP3 inflammasomes, and eventually lead to the formation of unstable plaques [33]
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Under iron-starved conditions, ferritin (a ubiquitously expressed protein that stores intracellular iron) is degraded via the autophagic pathway
Subgroup findings Only four single-sex-based animal studies 29,49,51,52 were found analyzing oxidative stress in the lung, of which three studies were conducted in male mice 29,49,51 and one study in female mice 52
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Although cotinine measurements obviously benefit these two associational research, their cross-sectional design disadvantages them
