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Eur J Clin Pharmacol 64(4):381385 Acknowledgements We would like to thank the PF-2400013 clinical team for providing the internal validation data sets for smoker and nonsmokers from the Phase 1 study for PF-2400013

Side effects of Chantix may include: Nausea Sleep problems (trouble sleeping or vivid, unusual, or strange dreams) Constipation Gas Vomiting Other side effects, which are less common but might be more severe, could include: Chest pain, including uncomfortable pressure, squeezing, and fullness

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PLoS ONE 10 , e0124841 (2015)