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These factors may potentially play a role in the perpetuation of chronic inflammation, thereby promoting the progression and development of EAOC (110, 111)

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These cells were embedded in matrigel to form 3D organoids, enabling the study of inflammatory responses and tissue remodeling processes within a controlled microfluidic environment

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Free radical biology & medicine 51 , 16011609, doi:10.1016/j.freeradbiomed.2011.06.020 (2011)

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Clinical relevance This study suggests how focal damage to an intervertebral disc might lead to loss of proteoglycans, collagen disruption and denaturation, and disturbed cell-matrix binding

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