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Across the patients we serve, an unexplained iron deficiency in an older adult with no bleeding source is one of the most reliable prompts to look at B12 and intrinsic factor antibodies

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Amphetamines disrupt VMAT2 function and vesicular uptake through a combination of mechanisms: The Weak Base Effect (pH Gradient Collapse) : Amphetamines are lipophilic weak bases (pKa of 9.9) that can readily diffuse across both the plasma and vesicular membranes to accumulate inside synaptic vesicles (Wimalasena 2011)