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In vivo, alveolar macrophages (AMs) serve as frontline immune cells, interacting directly with epithelial and endothelial cells to regulate inflammation, phagocytosis, and extracellular matrix remodeling

Tree tobacco contains lower concentrations of nicotine but does have high concentrations of anabasine, which acts similarly to nicotine in the body and is also poisonous

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The approach reflects a key challenge: e-cigarettes have only been widely used for about 20 years, meaning definitive proof based on long-term human outcomes could take decades