Common symptoms can include: Extreme fatigue Lethargy Loss of appetite headaches Feeling faint or dizzy Breathlessness Headaches Heart palpitations Tinnitus Additional symptoms of B12 deficiency can include psychological problems such as low mood, irritability, depression, cognitive changes, or blurred memory
Source: Li S, Chen X, Li Q, et al
Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes
14 , 124131.e121 (2016)
C., Selhub, J., Murphy, G
Nrf2/Keap1/ARE Redox Regulatory Pathway In response to oxidative or xenobiotic stress, Nrf2 dissociates from its inhibitor Keap1, translocates to the nucleus, and binds antioxidant response elements (ARE) to induce expression of genes involved in antioxidant defense and GSH biosynthesis (41)