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J., Walker, M., Wale, C

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6A, Nrf2-shRNA transfection significantly reduced Nrf2 expression (approximately 70%) in HBECs compared with negative control (NC) group

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In human A549 lung carcinoma cells, mitochondrial ROS were shown to mediate nicotine-induced activation of the transcription factor HIF-1, which could be abolished by the antioxidant N-acetylcysteine, the respiratory chain inhibitor rotenone or overexpression of mitochondrially targeted CAT

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