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Biological causes: Tobacco use induces neurochemical changes through stimulation of nicotinic acetylcholine receptors, which prompt the release of neurotransmitters that produce pleasure and satisfaction, according to the third chapter of the book Neurobiology of Addictions published in 2016 by the Oxford University Press

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It had been a lot of work and it ended with a lot of disappointment in years of waiting for it to be published

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[78] Though tobacco may be consumed by either smoking or other smokeless methods such as chewing, the World Health Organization (WHO) only collects data on smoked tobacco