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From there it followed the Silk Road to Persia and into the Mediterranean
infestans of other genes potentially involved in gene silencing such as class 1 RNase III, chromodomain proteins, DEAD-box helicases, histone deacetylases and histone methyltransferases, coming to the conclusion that proteins similar to Dicer, Ago and Histone deacetylases are essential for gene silencing in the oomycete 23