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The growing awareness of health risks associated with smoking has driven demand for low-tar and nicotine alternatives, albeit from a smaller consumer base compared to other segments

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For example, in 1929, Craven A advertised its cork-tipped cigarettes as unique in their throat protection they never catch my throat or are always kind to my throat. Certainly, Craven A was prophetic in its assertion that filters could be advertised as beneficial to health

To estimate street connectivity (factor 1), street networks were converted to points indicating junction locations (and representing connectivity) following the most common GIS approach identified by Jia et al

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While serious adverse events (SAEs) or other problems are not anticipated, serious and unanticipated and related adverse events or unanticipated problems involving risks to participants or others will be reported within 48 h to the Yale IRB and within 72 h to the relevant Serious Adverse Event Tracking and Reporting System at NIDA/NIH