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doi: 10.1016/s0140-6736(65)92336-6

[79] found if participants were to regularly use only e-cigarettes, their perceived risk of developing a heart attack next year was 34.6%, significantly lower than the perceived risk of regularly smoking only tobacco cigarettes (56.2%) and significantly higher than the perceived risk of no-nicotine use (15.2%)

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#5 Sure did, 160 for the pair

Nordic Cochrane Center, Cochrane Collaboration, 2001)

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