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Board Certified Reproductive Endocrinologist & Infertility SpecialistBoard Certified Reproductive Endocrinologist & Infertility SpecialistExpert AnswerMost insurances don't have set guidelines, but there are some that actually require a urine sample for tobacco, because tobacco can decrease the probability of success

In the United States, for example, the FDA has the authority to regulate e-cigarettes and has banned all flavors except tobacco and menthol in cartridge-based e-cigarettes

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And yetafter months of mounting tensionsthe FDA's tone abruptly brightened, and in a surprise about-face the drug was granted full approval and market exclusivity in January 1996, without a single substantial clinical trial submitted to demonstrate its effectiveness