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Figure 1 shows the steep rise in comments over the analysis period: Furthermore, January 2015 saw an average of approximately 350 comments per day on the subreddit, but by February 2019, this had increased to an average of 1,485 daily comments ( Figure 2 )

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It has already been reported that DNA damage, oxidative stress, and ethanol can activate these pathways [21, 26, 27, 38, 39]

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