10.1002/path.5489 81 PallanteP.MalapelleU.NacchioM.SgarigliaR.GalatiD.CapitelliL.et al (2021)
Alterations of Gpx4 and Acsl4 expression after sulfasalazine treatment
The proposed mechanisms are multi-faceted, likely involving anti-inflammatory actions, stabilization of the gut-vascular axis, and promotion of epithelial repair
Abbreviations A: Amyloid-beta AD: Alzheimers disease AF: Atrial fibrillation AMPK: AMP-activated protein kinase ATP: Adenosine triphosphate BBB: Bloodbrain barrier CAD: Coronary artery disease CAA: Cerebral amyloid angiopathy CVDs: Cardiovascular diseases DMF: Dimethyl fumarate ETC: Electron transport chain HF: Heart failure IMM: Inner mitochondrial membrane IMS: Intermembrane space IR: Insulin resistance I/R: Ischemiareperfusion LVH: Left ventricular hypertrophy MAPK: Mitogen-activated protein kinase MitoQ: Mitochondria-targeted coenzyme Q10 mPTP: Mitochondrial permeability transition pore mTOR: Mammalian target of rapamycin mtDNA: Mitochondrial DNA NAD: Nicotinamide adenine dinucleotide NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NO: Nitric oxide Nrf2: Nuclear factor erythroid 2-related factor 2 OMM: Outer mitochondrial membrane OXPHOS: Oxidative phosphorylation PGC-1: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha ROS: Reactive oxygen species SGLT2: Sodium-glucose cotransporter 2 SOD2: Superoxide dismutase 2 TGF-: Transforming growth factor-beta T2D: Type 2 diabetes ULK1: Unc-51 like autophagy activating kinase 1 VaD: Vascular dementia VCI: Vascular cognitive impairment VSMCs: Vascular smooth muscle cells eNOS: Endothelial nitric oxide synthase References Zhu XY, Shi MQ, Jiang ZM, et al
Reactive oxygen species in plants: their generation, signal transduction, and scavenging mechanisms
The last few decades have been associated with great expectations regarding clinical studies of the effect of low molecular antioxidants on human health
