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10.1371/journal.pone.0036563 17

However, the association with tobacco is plausible and justifies further investigation since psychotic illnesses are characterised by high levels of the neurotransmitter dopamine, and nicotine exposure increases the release of dopamine

and Enhanced capacity to cope with life stressors

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The MR approach minimized reverse causality, residual confounding, and misclassification, which potentially exist in observational studies