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Baseline elevated hippocampal rCBF or rCBV was also found to predict higher positive and negative symptom severity [38], poor functioning [38, 43], and transition to psychosis [38, 39, 44], and to normalize in those individuals who remit from the CHR-P state [40]

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This means that patients with CKD, who already have a higher CVD risk than the general population, are at an even greater risk if they smoke

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