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Since the constituents of HeatSticks may be different from that of combustible cigarettes, including flavourants and additives, it is plausible that the IQOS aerosol may contain substances not present in tobacco smoke. While some impacts of IQOS may be lower than that of cigarettes, others may be as bad or worse, Glantz said in summarizing the new research

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One of the drawbacks for recommending e-cigarettes is that the market is insufficiently regulated and health concerns have been raised about certain ingredients such as the various flavorings that might contain potential inhalation toxicants 35

Their grip on politicians and influence in policy have aided in molding a market landscape favorable for increased growth and profits

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