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Age-dependent effects of tobacco smoke and nicotine on cognition and the brain: a systematic review of the human and animal literature comparing adolescents and adults

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E-cigarette smoking appears to increase sympathetic tone, which is associated with a higher cardiovascular risk, and induce changes in electrocardiographic parameters of ventricular repolarization, which are linked to an elevated risk of sudden cardiac death, albeit to a lesser extent than traditional cigarette smoking [90,91,92]