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[And] the brand loyalty of 18-year-old smokers far outweighs any tendency to switch with age

Since nicotine is a weak base (pKa=8.0), at a higher pH, a larger portion of nicotine is unprotonated (free-base) and nicotine is more volatile.62 Because of higher pH, a significant proportion of nicotine is present in the gas phase of inhaled aerosol

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The report noted that in April 2025 almost all staff and contractors at the CDCs Office on Smoking and Health were terminated and a significant number of employees were fired or removed from the U.S