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It can also be dangerous, as evidenced by the number of people who have burned up themselves (and others) in their homes

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Cigarette smoke exerts cytotoxic and both proinflammatory and anti-inflammatory effects on nasal epithelial cells leading to increased reactive oxygen species (ROS) production, Toll-like receptor (TLR) 4 expression, lipopolysaccharide (LPS) and IL-17A synthesis [49,50,51]

Patients should be reassured about the safety, efficacy and low addictive potential of NRT, as misinformed concerns are a major cause of poor adherence

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