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A dog can become intoxicated with nicotine when the dose is at least 1 milligram per kilogram and can die at a dose of 9 milligrams of nicotine per kilogram

Fifty Years Experience of Reduced-Tar Cigarettes: What Do We Know about Their Health Effects? Inhalation Toxicology 15

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There have been no meaningful improvements in the safety profile of conventional cigarettes in our lifetime. And yet, Broussenko is seeing a resurgence in their use, particularly among his young patients and first-time smokers