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This is largely due to the rapid delivery of nicotine to the brain combined with harmful chemicals and behavioural reinforcement, such as lighting up and inhaling smoke

13 Thus as delta-9 carboxy-THC is the main metabolite for THC in urine, delta-8 carboxy-THC is the main metabolite for delta-8 THC in urine

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Fourth, in real word, the burden of different substance use subtypes is overlapping (people might use multiple substance), but GBD did not record the overlapping burden

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