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STAT3 directly interacts with the nicotine receptor nAChR1 to regulate the nuclear translocation of STAT3 and its binding to the Akt promoter region, thereby promoting the proliferation and migration of VSMCs and inflammation mediated by macrophages, which in turn causes atherosclerosis

The answers to the in-depth interviews were collected for qualitative analysis (see Supplementary file)

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Maintain the client in a supine position to reduce diaphragmatic pressure and visualize the wound

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