What are heat-not-burn cigarettes
The former is carefully researched by devoted - meaning, disinterested - scholars whereas the latter is conceived during business meetings by resentful, outdated researchers (Once they had been prominent )
Not many countries have done what the UK has done and I would be a bit more cautious

To help eliminate the use of animals in the risk assessment of TNCPs, it is recommended to: encourage pre-submission meetings between the agency and applicants to get early feedback on proposed NAMs provide consistent and transparent evaluations of application dossiers establish an international government-to-government collaboration initiative (similar to e.g., Accelerating the Pace of Chemical Risk Assessment [APCRA] for industrial chemicals) establish an open exchange forum between agencies, the regulated community, and other experts to discuss NAMs and how they can be applied for risk assessment purposes conduct retrospective reviews of submitted applications (such as PMTAs) with an aim to identify clear information needs for risk assessments organize regular workshops and webinars on the use of NAMs in risk assessment publicly share data to avoid duplicative testing and aid in read-across (e.g., the INTERVALS database) Collaborative efforts will advance the harmonized use and acceptance of reliable, fit-for-purpose NAMs that inform human biology

17 Goals interlinked The 2030 agenda lists 17 Sustainable Development Goals (SDGs) including 169 targets
"Why I Use Animals In My Research"